Etiology

The disease is the result of a complex interplay of HHV-8 with immunologic, genetic, and environmental factors {392}. Oral exposure to infectious saliva seems to be a potential risk factor for the acquisition of HHV-8 {1995}. HHV-8 is found in KS cells of all epidemiological-clinical forms of the disease {2242} and is detected in the peripheral blood before the development of KS. Nevertheless, it has been observed that a declined incidence of KS did not appear to be caused by a decline in HHV-8 transmission {1959}.

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