Differential diagnosis

This includes neuroendocrine carcinoma, adenoid cystic carcinoma, and adenosquamous carcinoma.

Neuroendocrine carcinoma typically lacks squamous differentiation, and is strongly positive for neuroendocrine markers. Adenoid cystic carcinoma, especially the solid variant, may resemble BSCC but adenoid cystic carcinoma has a myoepithelial component {132, 1337} and lacks in most instances squa-mous differentiaton. Furthermore, palpable metastatic cervical lymph nodes, quite common in BSCC, are very rare in adenoid cystic carcinoma {2128}. Adenocarcinoma and adenosquamous carcinoma can be distinguished from BSCC by the presence of true ductog-landular differentiation, and intracellular mucin.

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