Differential diagnosis

The differential diagnosis includes TC, AC, basaloid squamous cell carcinoma, malignant lymphoma, and a metastasis from a primary SCCNET of the lung. Compared to TC and AC, SCCNET is composed primarily of short spindle cells without nucleoli and exhibits more nuclear molding, necrosis and mitotic activity. In addition, SCCNET may be positive for thyroid transcription factor - 1 while the AC is usually negative {1097}. Basaloid squamous cell carcinoma

(BSCC) is a biphasic tumour composed of basal and squamous cell components that characteristically grow in a lobular pattern with central comedonecrosis. In addition, BSCCs often exhibit prominent nucleoli, cyst-like areas and hyalinosis and are negative for neuroendocrine markers and TTF. Malignant lymphomas are positive for leukocyte common antigen and negative for neuroendocrine markers. A metastasis from a primary SCCNET of the lung is based primarily on negative imaging studies of the lung.

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