Differential diagnosis

Low-grade LCS may be difficult to distinguish from chondroma. Grade 1 LCS show subtle increases in cellularity, with nuclear hyperchromasia and occasional binucleate forms. Irregular clustering of cell groups, or "cluster disarray" is found

Osteosarcoma

Definition

Osteosarcoma is a malignant tumour characterized by the direct formation of osteoid by neoplastic cells.

Fig. 3.64 Osteosarcoma of the larynx, characterized by large, pleomorphic osteoblasts and osteoid production.

Fig. 3.64 Osteosarcoma of the larynx, characterized by large, pleomorphic osteoblasts and osteoid production.

in all grades of LCS {1152} and may be a useful feature in the distinction of low-grade chondrosarcoma from chondroma. The diagnosis of laryngeal chondroma should be reserved for small (less than 1-2 cm), clinically insignificant lesions, without discernible atypia. Any recurrent cartilaginous tumour of the larynx should be considered a chondrosar-coma {255}. Chondrometaplasia is characterized by small (less than 1 cm) nodules of bland, fibroelastic cartilage which are found in the submucosal soft tissue of the glottic region {747,1161}.

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