The differential diagnosis of EMC includes all primary salivary gland tumours that are predominantly formed by clear cells: pleomorphic adenoma, myoepithelioma, oncocytoma and mucoepidermoid carcinoma. Differential diagnosis with clear cell carcinoma, NOS relies on the demonstration of the peculiar amyloid-like quality of the stroma and on the absence of myoepithelial markers. Metastatic kidney and thyroid carcinoma may be distinguished using immunohis-tochemistry; CD10 and high-molecular weight cytokeratin in the former and thy-roglobulin in the latter. EMC foci can be encountered within carcinoma ex pleomorphic adenoma as part of the carcinomatous component.
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