Differential diagnosis

This includes squamous papilloma, ver-rucous carcinoma, and exophytic SCC. Though squamous papilloma and verru-cous carcinoma share similar architecture with PSCC, the latter is easily recognized by atypia of the squamous epithelium {743}. Most PSCC strongly express p53 immunohistochemically {2488}. The distinction between exophytic and papillary SCC can be difficult as the criteria for diagnosing exophytic SCC are not clearly delineated {171,2602}. In general, the papillary stalks of PSCC are much better defined than in exophytic SCC.

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