Combined small cell carcinoma neuroendocrine type

Small cell carcinoma, neuroendocrine type (SCCNET) associated with a squa-mous or adenocarcinomatous compo nent are referred to as combined or composite carcinomas. They are unusual, representing less than 10% of all SCCNETs of the larynx. Only 14 cases have been described as of 2004. Most, if not all, have been associated with a squamous cell carcinoma, either in-situ or invasive {1201}. Treatment and prognosis is otherwise similar to that of a "pure" SCCNET.

N. Gale B.Z. Pilch D. Sidransky W.H. Westra J. Califano

Table 3.5 Classification schemas that histologically categorize precursor and related lesions

2005 WHO Classification

Squamous Intraepithelial Neoplasia (SIN)

Ljubljana Classification Squamous Intraepithelial Lesions (SIL)

Squamous cell hyperplasia

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