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Fig. 3.63 Laryngeal chondrosarcoma. A Low power view demonstrating the characteristic lobulated growth pattern. B Moderately differentiated (grade 2) chondrosarcoma with greater degree of cellularity and nuclear pleomorphism. C Well differentiated (grade 1) chondrosarcoma with mild nuclear atypia and hyper-chromasia. D Focal metaplastic bone formation in a laryngeal chondrosarcoma.

Fig. 3.63 Laryngeal chondrosarcoma. A Low power view demonstrating the characteristic lobulated growth pattern. B Moderately differentiated (grade 2) chondrosarcoma with greater degree of cellularity and nuclear pleomorphism. C Well differentiated (grade 1) chondrosarcoma with mild nuclear atypia and hyper-chromasia. D Focal metaplastic bone formation in a laryngeal chondrosarcoma.

High-grade LCS are generally considered rare; although in the largest reported series they comprised 5% {2598}. Metaplastic bone formation and calcification are also common to LCS. Myxoid change is infrequent. Dedifferentiated and clear cell variants of LCS have been reported, albeit rarely {28,255,1888, 2598}. Dedifferentiated chondrosarcoma is characterized by the presence of two distinct components: well-differentiated chondrosarcoma and a high-grade, non-cartilaginous sarcoma. Clear cell chon-drosarcoma is composed of chondro-

cytes with abundant clear cytoplasm and prominent cell membranes. LCS, similar to chondrosarcoma found elsewhere, expresses S-100 protein (strongly) and vimentin (focally) in immunohistochemi-cal studies {255, 1888}.

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