There is typically a starry sky pattern created by interspersed histiocytes. The lymphoma cells appear monotonous and medium-sized, with coarse chromatin, multiple small nucleoli and a small amount of basophilic cytoplasm. The cellular outline usually appears squared off. Frequent mitotic figures and apoptotic bodies are constant features.
Immunoprofile. B-cell lymphomas express pan-B markers such as CD19, CD20, CD22 and CD79a. Some DLBCLs can express CD10 and/or BCL6. Within the group of low-grade B-cell lymphomas, follicular lymphoma is characterized by CD10 and BCL6 expression, mantle cell lymphoma CD5 and cyclin D1 expression, and extranodal marginal zone B-cell lymphoma none of these markers. Bcl-2 Immunoreactivity is helpful for distinction of follicular lymphoma from reactive follicular hyperplasia.
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