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Fig. 3.23 Acantholytic squamous cell carcinoma. A Marked acantholysis of squamous cells giving rise to anastamosing empty spaces with pseudoglandular appearance. B Acantholytic channels, interningled with dilated capillary blood vessels, mimicking angiosarcoma.

A. Cardesa N. Zidar L. Alos

Table 3.2 Differential diagnosis between adenosquamous carcinoma and mucoepidermoid carcinoma of the head and neck

Adenosquamous carcinoma

Mucoepidermoid carcinoma

Squamous carcinoma in-situ

No squamous carcinoma in-situ

Origin from squamous epithelium

Origin from seromucinous ducts

Keratin pearls

Limited keratin pearls

Glands at lower invasive parts

Glands widely intermingled

No lobular arrangement

Lobular arrangement

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