OSA is characterized by sleep disruption and hypoxia, leading to noradrenergic activation, elevated blood pressure, ß-adrenergic receptor desensitization, and increased levels of proinflammatory cytokines. Successful treatment of OSA with CPAP reverses many of these adverse effects, including elevated inflammatory markers, potentially by increasing the clearance of NE.

Acknowledgments. This work was supported by grants HL57265, HL36005, HL44915 and HL40102 from the National Institutes of Health and the UCSD General Clinical Research Center (M01RR00827).

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