Immune activation modulates sleep by influencing brain neurons involved in the regulation and maintenance of sleep-wake cycles and arousal states. The precise mechanisms by which this occurs are not completely established, but seem to follow from direct influences of immune-derived mediators, such as cytokines, on sleep/wake neurons (Opp 2005), and/or via activation of peripheral viscerosensory neurons driving brain neural circuits that modulate arousal states in response to internal and external challenges. In this chapter we will review the organization of visceral sensory pathways that carry immune-related information to the brain, and recent findings regarding the brain neurocircuitry connecting immune-brain interfaces with arousal network nuclei that influence sleep-wake states.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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