The fundamental function of the immune system is to distinguish entities within the body as "self" or "nonself" and to eliminate those that are nonselfs. Once immune system is activated, several cytokines will be secreted from lymphocytes that are in proliferation and differentiation processes. On search of mechanism of sleep, links between the innate immune system and sleep regulation have been found out through the cytokine network. The link was unexpected initially, however, as much knowledge of sleep mechanism has been accumulated, the links seemed one of key element of significance of sleep.

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