Narcolepsy is genetically complex and environmentally influenced. Although the HLA DQB1*0602 remains the unique established genetic risk factor, future studies may focus in identifying new genetic susceptibility factors, environmental factors and the study of gene-environment interactions, involving in hypocretin cell death. The cause of this focal neurodegeneration remains a mystery although an autoimmune hypothesis is likely. A transient and focal inflammatory process targeting hypocretin neurons may have occurred around disease onset and disappeared shortly thereafter.

Further studies that focus on reactivity of serum and/or CSF to other components of the hypocretin neurotransmission system, and on T-cell autoimmune response directed against neuroantigens are warranted. Finally, the efficacy of immune-based therapies in narcolepsy needs to be confirmed in larger double blind placebo controlled trials.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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