Evidence for the presence of a NO-mediated signalling in the cerebral vasculature has come from several lines of study. First, using antibodies raised against purified NOS, Bredt and colleagues have shown that the enzyme is, among other sites in the rat brain, localized to the endothelial layer of large cerebral blood vessels and nerve fibers in their adventitia; the origin of these perivascular "nitrergic" nerve fibers is the pterygo/sphenopalatine ganglion . While NOS has not been demonstrated his-tologically in resting vascular smooth muscle cells, treatment with endotoxin and proinflam-matory cytokines has been shown to induce
Was this article helpful?
The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.