Neurosurgical Management Of Highgrade Gliomas

Histologically defined anaplastic oligodendrogliomas

Histologically defined anaplastic oligodendrogliomas

Group 1:

combined, isoiated ip + 19q ioss

Group 2

ip ioss 'other'

Group 3:

TP53 mutation

Group 1:

combined, isoiated ip + 19q ioss

Group 2

ip ioss 'other'

Group 3:

TP53 mutation

Number of patients Age

Response rate Duration response Survival from dx

43 51 30 52

>31 months 11 months 7 months 5 months

>123 months 71 months 71 months 16 months

Fig. 10.3. Grouping of patients with anaplastic oligodendroglioma by molecular genetic profiles defines specific prognostic groups. Group 2 includes patients with Ip loss and either no 19q loss or "other" molecular genetic changes, including TP53 mutation, PTEN mutation, 10q loss, EGFR amplification or CDKN2A deletion. Group 4 patients have mutations including PTEN, 10q loss, EGFR amplification, CDKN2A deletion, or ring enhancement on CT. (Courtesy of Ino et al. [15]).

be determined when considering the prognostic impact of other treatment variables on outcome for HGGs.

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