Neurosurgical Management Of Highgrade Gliomas

chloride channel. Propofol is a fast-onset, short-acting drug. Propofol decreases the CBF by 30% to 50%, with a 35% diminution of the CMRO2, preserving CO2 reactivity. Propofol decreases ICP with a concomitant decrease of MAP.

Narcotics currently used during anesthesia are synthetic phenylpiperidine derivatives and include fentanyl, sufentanil, alfentanil and remifentanil. They are pure opioid receptor agonists, and, unlike morphine, do not liberate histamine. These drugs are all ultrashort- to short-acting drugs. They are used as anesthetic adjuvant, but may be used as the main anesthetic agent. The effect of these drugs on cardiovascular and cerebral dynamics is quite variable. Remifentanil and fentanyl seem to have negligible effect on ICP, while sufentanil and alfentanil may increase it. Mainly because of their effect on MAP, they tend to decrease the CPP, sometimes below the range of autoregulation. Again, of the four drugs, fentanyl has the smallest effect on CPP. Sufentanil may even decrease CBF in a dose-dependent manner under anesthesia. Alfentanil seems to have negligible effects on both CBF and CMRO2. Narcotics maintain CO2 reactivity. Narcotics are not brain protectants.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

Get My Free Ebook


Post a comment