Neurosurgical Management Of Highgrade Gliomas

as marimistat, which inhibit matrix metallopro-teases elaborated by tumor cells that facilitate tumor cell migration by digesting ECM components. Another therapy has used injection of I-131-labeled antibodies into resection cavities after surgery to target the ECM protein tenascin, which is unique to the ECM of HGGs but not normal brain, and appears to promote proliferation and angiogenesis as well as tumor cell migration. Other treatments specifically targeting invasion that require neurosurgical intervention are likely to emerge in the future, such as the use of genetically engineered neural stem cells, which, in animal models, appear to "track down" isolated invasive tumor cells and facilitate localized conversion of prodrugs into cytotoxic compounds [11].

Was this article helpful?

0 0
Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

Get My Free Ebook

Post a comment