Table 10.2. Survival for HGGs by RTOG RPA (courtesy of Curan et al. )
RPA class, respectively. These studies confirmed prognostic factors found in most other studies, including age, Karnofsky performance status (KPS), histological grade, mental status, length and/or presence of neurological symptoms, surgical resection and adequate radiation. The predictors of outcome at the time of HGG recurrence have been evaluated in a large review of 375 patients enrolled on phase II treatment trials, which reported median survival for all recurrent HGGs of 30 weeks, with overall survival rates at 1 year of 47% and 21%, for AA and GBM patients respectively . This study confirmed the prognostic significance of histology (AA vs GBM), KPS and prior intensive therapy, which were found in other previous studies . The appropriate choice of surgical candidates and the aggressiveness of resection for primary and recurrent HGGs, discussed below, must account for these histological and clinical characteristics that dominate clinical outcome.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.