Neurosurgery

in about 50% of sporadic meningiomas, including those tumors that do not harbor mutations in the NF-2 gene. Interestingly, alterations in NF-2 gene and protein expression were rarely found in the meningothelial meningioma variant, suggesting the existence of other meningioma susceptibility gene(s).

In spite of intense study of NF-2 gene functions, the molecular mechanisms that enable the NF-2 protein to function as a tumor suppressor are largely unknown. As a member of the band-4.1 superfamily of proteins, the NF-2 protein is considered important in the regulation of actin cytoskeleton and in interactions between cyto-plasmic proteins and membranes. A possible physiological role of the NF-2 protein was suggested by its antiproliferative effect on some cell types, including meningioma cells. The NF-2 protein has also been shown to modulate cellular adhesion [38]. Further clues about NF-2 protein functions come from identification of cellular proteins that physically interact with the NF-2 protein. The list of NF-2 protein-interacting molecules includes:

II-spectrin, an actin-binding protein, extracellular matrix receptor (31-integrin, and regulatory cofactor for an Na+/H+ exchanger. It is, therefore, possible that mutated/inactivated NF-2 protein contributes to meningioma tumorigenesis by impairing signal transduction from the extracellular matrix and/or ion channels to the cytoskeleton, and thus deleteriously alters molecular pathways that control cell differentiation, growth and survival. In addition, naturally occurring mutant forms of NF-2 protein, but not the full-length NF-2 protein that exhibits growth-suppressive activity, physically interact with a novel coiled-coil protein of unknown function, termed "SCHIP-1" [39]. Clearly, the NF-2 protein is a tumor suppressor that is regulated in a complex manner to control diverse biological functions.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

Get My Free Ebook


Post a comment