adults, the actual incidence of this syndrome is unknown and the pathophysiology remains unclear. However, given the high mortality reported in children, and apparently conclusive data in a clinical trial (as yet unpublished), the use of propofol infusion in children is currently not advised. In adults, where indicated, the benefits of propofol outweigh this potential risk and should not be withheld from patients in the neurointensive care unit. However, prolonged infusion for more than 1 week, at doses greater than 5 mg/kg/h, is not advised, and the infusion should immediately be discontinued should any acidosis or cardiac dysfunction develop. In addition, propofol in high doses will result in systemic hypotension, often necessitating the use of vasopressors for blood pressure support.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.