of inheritance consistent with compiled pedigrees, but no single mendelian model has the overall best fit, suggesting genetic heterogeneity.
Familial IAs are not rare, accounting for 7-20% of patients with aneurysmal SAH. In one study of 8,680 individuals, the prevalence of asymptomatic aneurysms in the subgroups with and without a family history was 10.5 and 6.8%, respectively . Approximately one-third of asymptomatic members of affected families will have evidence of UIA on angiography. The relative risk of siblings of SAH patients suffering a hemorrhage is six times that of the general population, with a threefold increased risk in the parents - an overall fourfold increased risk in first-degree relatives.
Familial aneurysms tend to rupture at a smaller size and at a younger age than sporadic cases and often display genetic anticipation, with hemorrhage occurring at progressively younger ages in each successive generation. The occurrence of aneurysms at identical and "mirror" sites is more frequent in familial cases and appears to be a function of the degree of kinship between affected individuals.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.