monitoring of drug levels, EEG, cardiac output and CBF.
Propofol is now frequently used in the ICU setting for ICP control. In the acute setting, and over relatively short periods of time (hours to days), the agent has an effective half-life of 2-4 minutes. The drug decreases CBF, ICP and CMRO2 and induces less cardiac depression than barbiturates. Because of its short half-life, it has also shown utility for neuroleptic anesthesia. Propofol is also useful for sedation of agitated patients in whom serial neurological exams are necessary. Once the propofol infusion is stopped, within 10-20 minutes effective blood levels have dropped to near zero. Untoward side-effects include negative inotropy, respiratory depression and prolonged clearance after large doses.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.