Table 11.1. Differential diagnosis of neoplasms and "tumor-like" lesions of the sellar region

Tumois of adenohypophyseal origin

Pituitary adenoma Pituitary carcinoma Tumors of neurohypophyseal origin

Granular cell tumor

Astrocytoma of posterior lobe and/or stalk (rare) Tumors of non-pituitary origin

Craniopharyngioma Germ cell tumors

Gliomas (hypothalamic, optic nerve/chiasm, infundibulum) Meningioma Hemangiopericytoma Chordoma Hemangioblastoma Lipoma

Giant cell tumor of bone


Fibrous dysplasia

Sarcoma (chondrosarcoma, osteosarcoma, fibrosarcoma) Post-irradiation sarcomas Paraganglioma Schwannoma Glomangioma Esthesioneuroblastoma Primary lymphoma Melanoma Cysts, hamartomas and malformations Rathke's cleft cyst Arachnoid cyst Epidermoid cyst Dermoid cyst Gangliocytoma Metastatic tumors Carcinoma Plasmacytoma Lymphoma Leukemia Inflammatory conditions Infection/abscess Mucocele

Lymphocytic hypophysitis Sarcoidosis

Langerhans' cell histiocytosis Giant cell granuloma Vascular lesions

Internal carotid artery aneurysms Cavernous angioma

NB. Lesions in italics are discussed in the text.

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