Fig. 3.2. a An inactive plaque of MS at autopsy, packed with lipid-filled gitter cells (red in the original), the sharp edge and the uniformly plump macrophages indicating that the lesion is at least many months old. NP4249, oil-red-O-hematoxylin (ORO-H). b A small focus of activity at the edge of another old plaque in the same patient, the gradation in size of the microglia as they digest the myelin into ORO-positive droplets indicating that the lesion began less than a few days before death. NP4249, ORO-H. c Another small focus of activity in another case of MS, the progressively decreasing sizes of the myelin debris (blue in the original) phagocytosed by microglia and converted into periodic acid-Schiff (PAS)-positive granules (red in the original) paralleling the lipid production in b. NP2169, Luxol-fast-blue-PAS-hematoxylin (LFB-PAS-H).
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.