Neuromuscular Blocking Drugs

Neuromuscular blocking drugs, or muscle relaxants, facilitate intubation of the trachea and mechanical ventilation of the lungs, and prevent movement during surgery. They are charged molecules that do not cross the blood-brain barrier, and so have no direct cerebral effects. However, they may indirectly influence the central nervous system via cardiovascular side-effects, histamine release and active metabolites. These drugs may be depolarizers or non-depolarizers, depending on their mechanism of action at the neuromuscular junction.

Depolarizing drugs (of which succinylcholine - Anectine - is now the only commonly used example) act very rapidly, have a short duration of action and produce excellent intubating conditions. Succinylcholine remains the drug of choice for rapid-sequence intubation to protect at-risk patients against aspiration of stomach contents. It produces initial muscle fascicula-tion and, frequently, post-anesthetic myalgia. A non-depolarizing-type block may be produced with repeated doses. Vagal stimulation may occur, inducing bradycardia and asystole. Serum potassium concentrations increase

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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