Malignant Tumors of the Axial Skeleton

Malignant tumors of the axial skeleton can either be primary (arising from the bony skeleton itself) or metastatic. The most common metastatic spinal column tumors are breast, lung and prostate malignancies, while multiple myeloma, chordoma, chondrosarcoma, osteo-genic sarcoma and Ewing's sarcoma are the more common primary malignant axial skeletal neoplasms. Metastasis can result from direct extension or hematogenous spread. Primary malignant axial skeletal neoplasms and met-astatic tumors most frequently involve the vertebral body. Malignant tumors of the spinal column are 25-40 times more likely to be metastatic than primary [1-4,6].

Chordomas, originally described by Virchow, are tumors originating from the primitive noto-chord. Being tumors of the axial skeleton and the skull base, chordomas account for 1-2% of all skeletal sarcomas. Chordomas are histo-logically low-grade, locally invasive tumors; however, metastases may occur in 5-43% of chordoma cases. More than 50% of these lesions are located in the lumbosacral region, 35% in the clival and cervical area, and the remainder are spread throughout the vertebral column. Chordomas are the most common primary neoplasms of the sacrococcygeal region and occur predominantly in the fifth and sixth decades of life. Neurological deficit in the form of bowel and bladder dysfunction may be present at the

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

Get My Free Ebook

Post a comment