• High-grade gliomas are the most common primary cerebral neoplasms in adults and the majority of these tumors are glioblastoma multiforme and anaplastic astrocytoma.
• High-grade gliomas can either arise de novo or arise from malignant degeneration of low grade gliomas.
• Treatment of high-grade gliomas includes confirmatory biopsy or surgical resection followed by radiation therapy. Chemotherapy can also be considered.
• Important predictors of survival include age, histological grade, Karnofsky performance status and adequacy of treatment.
• Despite advances in imaging, surgical techniques to maximize resection, and chemotherapy and radiation therapy techniques, the prognosis for survival beyond 2-3 years remains poor.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.