There are many heritable connective tissue disorders that have been associated with IAs. It is not known to what degree they contribute to total prevalence of UIAs, although it is probably small, at approximately 5%. Recognition of an underlying generalized connective tissue disorder is of considerable importance, although marked phenotypic heterogeneity often complicates the diagnosis of these disorders.
The most commonly inherited disorders that have been reported to be associated with IAs include autosomal dominant polycystic kidney disease, Marfan's syndrome, pseudoxanthoma elasticum, Ehlers-Danlos syndrome and alpha-1 antitrypsin deficiency.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.