A multitude of cytotoxic and cytostatic chemotherapeutic regimens have been used for the treatment of HGGs and, with the exception of PCV therapy (procarbazine, CCNU & vincristine) for AO and AOA, the results have been disappointing. A complete review of the various chemotherapy protocols is beyond the scope of this chapter but a recent meta-analysis, which drew on data from 12 randomized trials of chemotherapy for adult HGGs, demonstrated an increase in 1-year survival from 40% to 46% and an overall 2-month increase in median survival . An important exception is the demonstrated durable response and prolonged survival for AO and AOA associated with deletions of the 1p and 1p+19q chromosomes (see Fig. 10.3 and text above) .
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.