The near future holds great promise for work on the zebrafish because of the flood of interesting mutations that emerged from the large-scale screens (Development, vol. 123, 1996). The continued generation of a genetic map is a crucial development and has allowed the first positional cloning projects to be started (23). Other techniques are being tackled, such as the establishment of a mouse ES cell equivalent, which is yet to be obtained in any other vertebrate, and the use of viruses for transgenesis and insertional mutagenesis. The future is becoming increasingly more promising for the studies of developmentally regulated genes in this organism.
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