Planar Signals in the Context of Prospective Neural and Epidermal Interactions

The sandwich explants described above consist of the dorsal 90-120° of the embryo, which includes little or none of the prospective epidermal ectoderm. Thus, in these explants, planar signals from the Organizer act on the prospective neural tissue in the absence of any influences from the prospective epidermis. Since there is evidence that epidermal-neural interactions pattern the neural tissue and regulate its morphogenesis (57-61), we have developed several types of explants that allow planar signals from the Organizer to act in the context of also having planar neural-epidermal interactions.

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