Uaa

Apolipoprotein B48

Newly formed stop codon mRNA

mRNA

Several proteins of the mammalian nervous system undergo A to I editing in the coding sequence of their mRNAs.

FIGURE 12.24 Editing of Trypanosome mRNA

The guide RNA base pairs along a specific region of the trypanosome mRNA. The extra adenine (A) of the AGA sequence in the guide RNA is used as a template to insert uracil (U) into the mRNA. (Note: some slightly distorted duplex RNA structures allow guanine, as in the AGA sequence shown, to pair with uracil.)

Trypanosome mRNA

Trypanosome mRNA

^ Guide RNA

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