Transcriptional Coupling of Repair

If the template strand of DNA is damaged in a gene that is being transcribed the RNA polymerase may grind to a halt. Such damage is repaired preferentially by what is known as transcription-coupled repair. If the mutation is found in the non-template strand, the mutation is less likely to be repaired. This implies that repairing the template strand is of higher priority. In bacteria the transcription-repair coupling factor, transcription-coupled repair Preferential repair of the template strand of DNA that may be transcribed aa aa

Uv irradiation causes pyrimidine dimer to form

Uv irradiation causes pyrimidine dimer to form aa aa

Photoreactivating enzyme complexes with dimer

Photoreactivating enzyme complexes with dimer

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Dimer cleaved and enzyme released

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