Overview of DNA Repair

DNA may be damaged by a variety of agents including chemical mutagens and radiation or by spontaneous reactions of the DNA itself as discussed in the previous chapter. Damage to DNA may cause breaks in the chromosomes or may block replication and so result in the death of the cell. Some types of DNA damage may cause mutations, but other types do not. A mutation may occur if the damage is not repaired

Rad proteins Group of proteins involved in recombination and repair of DNA damage in yeast and animal cells. Rad51 corresponds to the prokary-otic RecA protein

DNA Mismatch Repair System 379

TABLE 14.01 DNA Repair Systems of Escherichia coli

Repair System

Genes

Mechanism or Function

Mismatch repair

dam

DNA adenine methylase

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