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FIGURE 3.04 Nucleotides Are Joined by Phosphodiester Linkages

The nucleotides that form the backbone of DNA and RNA are joined together by linkages involving their phosphate groups. One nucleotide is linked via its 5'-carbon to the oxygen of the phosphate group and another nucleotide is linked via its 3'-carbon to the other side of the central phosphate. These linkages are termed phosphodiester groups.

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