Irp1 Binding

Ribosomal proteins of bacteria regulate their own synthesis by binding to their own messenger RNA.

Some Regulatory Proteins Can Activate Translation 287

FIGURE 11.05 Regulation of Synthesis of Ribosomal Proteins in Bacteria

The mRNA shown at the top of the figure contains a loop, a ribosome binding site (RBS) and structural genes coding for several ribosomal proteins. These proteins prefer to bind rRNA. In situations where there is insufficient rRNA to bind the ribosomal proteins, one of them binds to its own mRNA and alters its configuration so blocking the ribosomal binding site. This prevents synthesis of excess ribosomal proteins.

Some Regulatory Proteins Can Activate Translation 287

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