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Overview of Recombination

Molecular Basis of Homologous Recombination

Single-Strand Invasion and Chi Sites

Site-Specific Recombination

Recombination in Higher Organisms

Overview of DNA Repair

DNA Mismatch Repair System

General Excision Repair System

DNA Repair by Excision of Specific Bases

Specialized DNA Repair Mechanisms

Photoreactivation Cleaves Thymine Dimers

Transcriptional Coupling of Repair

Repair by Recombination

SOS Error Prone Repair in Bacteria

Repair in Eukaryotes

Double-Strand Repair in Eukaryotes

Gene Conversion

Overview of Recombination 369

FIGURE 14.01 Two Crossovers Result in Recombination

Two paired double-stranded DNA molecules align related regions (A with a; B with b, etc.). Breakage occurs in each paired DNA molecule followed by crossing over and rejoining of the ends. This exchanges part of one DNA strand with another.

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