Kpi

gene. Since this will completely destroy the function of the protein, intercalating agents are highly hazardous mutagens.

A teratogen is an agent that causes abnormal development of the embryo, which results in gross structural defects. Teratogens may or may not cause mutations. The most famous example is thalidomide, which resulted in the birth of malformed teratogen An agent that causes abnormal embryo development leading to gross structural defects or monstrosities

FIGURE 13.15 Intercalating Agents

An intercalating agent, such as acriflavin, can insert itself between base pairs and mimic a whole extra base pair. When replication occurs, the intercalating agent causes an extra base pair to be inserted into the new DNA. Commercial acriflavin is actually a mixture of the structure shown plus the derivative without the N-methyl group.

FIGURE 13.15 Intercalating Agents

An intercalating agent, such as acriflavin, can insert itself between base pairs and mimic a whole extra base pair. When replication occurs, the intercalating agent causes an extra base pair to be inserted into the new DNA. Commercial acriflavin is actually a mixture of the structure shown plus the derivative without the N-methyl group.

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