The twenty amino acids that comprise proteins vary greatly in their chemical and physical properties.

a wide range of properties and capabilities, including a great variety of possible 3-D structures. The amino acids may be classified into groups depending on their physical and chemical characteristics. The major division is between those with hydrophilic (water-loving) and those with hydrophobic (water-hating) R-groups. Glycine has only a single hydrogen atom as its side chain, so it does not really fit into either group.

The hydrophilic amino acids may be subdivided into basic, acidic and neutral. Basic amino acids contribute a positive charge to the protein whereas acidic residues provide a negative charge. Strictly, this refers to the situation in solution within the physiological pH range. Neutral polar residues have side chains that are capable of forming hydrophilic Water-loving;readily dissolves in water hydrophobic Water-hating;repelled by water and dissolves in water only with great difficulty

Hydrophilic amino acids

Basic amino acids h H

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