Both single-copy and multicopy plasmids regulate their copy number carefully. However, the regulatory mechanisms differ significantly for the two groups. High copy number plasmids limit the initiation of plasmid replication once the number of plas-mids in the cell reaches a certain level. These plasmids are sometimes said to have "relaxed" copy number control. In contrast, single copy plasmids have "stringent" copy number control as their division is more tightly regulated and they replicate only once
Control of Copy Number by Antisense RNA 433
Circle continues to roll
Third new strand Second new strand First new strand
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