Ch

MutS

MutS

MutH MutH

MutL

MutH MutH

One of MutH subunits binds to methyl group and

DNA in between loops out

MutS is still bound to G/T mismatch

MutS

MutH MutH

MutL

One of MutH subunits binds to methyl group and

DNA in between loops out

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