Ch

(Non-methylated) Igf2 gene

Fertilization

FIGURE 10.16 Imprinting and Development

The two copies of the same gene inherited from each parent are not always methylated in an identical manner. A) Here the Igf2 gene from the mother has methyl groups and is inactive, whereas the non-methylated gene from the father is active. B) After fertilization, the embryo has one active and one inactive Igf2 gene. C) Most methylation patterns are reprogrammed in the early embryo but a few survive, resulting in imprinting.

B) Diploid zygote

Igf2 gene

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