Ch

Methyl cytosine

BINDING PROTEIN f ARRIVES

FIGURE 10.15 Silencing Starts with Methylation

A) CG regions on the DNA are B) methylated. C) A methyl cytosine binding protein (MeCP) is attracted to the methylated sites and D) histone deacetylase (HDAC) is bound to both MeCP and DNA. E and F) The consequence is deacetylation of the histone tails and aggregation of nucleosomes to form heterochromatin.

MeCP

CH3 1

CH3> 1

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