Histopathology

Most colorectal cancers are moderately well differentiated glandforming adenocarcinomas. Less common cell types include signet ring adenocarcinoma (see Linitis Plastica in Pitfalls section), adenosquamous carcinoma, squamous cell carcinoma, small cell carcinoma, choriocarcinoma and medullary cell carcinoma. Colorectal carcinoid tumours occasionally occur (more commonly in the rectum) and arise in the submucosa. Sarcomas (usually leiomyosarcoma) are more rare, comprising up to 0.3% of colorectal tumours.

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