Part of the function of HSFs stems from their regulation of the expression of chaperone and Hsp genes. This is true for HSF1 in normal constitutive conditions, in contrast to the first descriptions made. But many of the effects are due to the regulation of genes unrelated to the Hsp genes, such as growth factor genes. The rules governing the binding of HSF to HSE, and the transcriptional activation of the downstream genes remain largely unknown (Trinklein et al. 2004b). More global roles, such as the regulation of the chromatin state in the case of HSF2, must also be considered.
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