Synthetic Nanopore Detectors

Synthetic nanopores are likely to be more stable and may tolerate a wider range of conditions than protein nanopores. The engineering challenge for applying a synthetic nanoscale pore to DNA sequence detection is to make the device to the scale of DNA: 1 to 2 nm in diameter and ~0.4 nm thick. Several investigators have developed fabrication methods to produce synthetic pores approaching these dimensions.24-26,28-31 DNA detection using ionic current has been demonstrated for most of these nanoscale pores; work is now going on to combine more sensitive methods of detection with the

26,28,32,60-62 synthetic pores.26,28,32,60-62

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