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Introduction 16-1

Basic Requirements for Single-Molecule Detection 16-2

Signal-to-Noise Ratio and Signal-to-Background Ratio • Ensure That the Signal Actually Originates from a Single Molecule

Optical Techniques for Single-Molecule Detection 16-6

Laser-Induced Fluorescence • Near-Field Scanning Optical Microscopy • Surface-Enhanced Raman Spectroscopy • Optical Tweezers

Applications in Fixed and Living Cells 16-13

Molecular Motors • Cell Signaling • Protein Conformational Dynamics • Ion Channels • Monitoring Reactions and Chemical Constituents in Living Cells Conclusion 16-16

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