Molecular Biology of Drug Addiction

Edited by

Rafael Maldonado

Laboratory of Neuropharmacology Health and Life Sciences School Universitat Pompeu Fabra Barcelona, Spain

Humana Press ¡^rC Totowa, New Jersey

© 2003 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com

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Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, since new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occur, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further, it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publishers, editors, and authors are not responsible for errors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication. This publication is printed on acid-free paper. CH5

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Cover illustration: Disruption of the CREB gene in brain by Cre/loxP-mediated recombination (Chapter 2, Fig. 5). See complete illustration on p. 33 and discussion on p. 30.

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Library of Congress Cataloging-in-Publication Data

Molecular biology of drug addiction / edited by Rafael Maldonado p. cm.

Includes bibliographical references and index. ISBN 1-58829-060-3 (alk. paper)

1. Drug abuse--Molecular aspects. I. Maldonado, Rafael. RC564 .M638 2003 616.86--dc21

2002024057

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