Effects of Stress on the Behavioral Response to Psychostimulants

Sobriety Success

At Home Drug Withdrawal

Get Instant Access

Stressful conditions have been shown to increase the psychomotor stimulant effects of drugs of abuse (48-51), a phenomenon often referred to as stress-induced sensitization. Mild food restriction (10-20% of body-weight loss) increases locomotor activa-

Fig 3. Stress-induced corticosterone secretion mediates stress-induced sensitization to cocaine. (A) Stress (food restriction) increases the locomotor response to an injection of cocaine (10 mg/kg). Blockade of stress-induced secretion of corticosterone by treatment with metyrapone (100 mg/kg) prevents this stress-induced effect. (B) Food restriction increases dopamine levels in response to cocaine (10 mg/kg). Blockade of stress-induced secretion of corticosterone by treatment with metyrapone (100 mg/kg) prevents this stress-induced effect. (Modified from Marinelli et al. [13] and Rougé-Pont et al. [71]).

Fig 3. Stress-induced corticosterone secretion mediates stress-induced sensitization to cocaine. (A) Stress (food restriction) increases the locomotor response to an injection of cocaine (10 mg/kg). Blockade of stress-induced secretion of corticosterone by treatment with metyrapone (100 mg/kg) prevents this stress-induced effect. (B) Food restriction increases dopamine levels in response to cocaine (10 mg/kg). Blockade of stress-induced secretion of corticosterone by treatment with metyrapone (100 mg/kg) prevents this stress-induced effect. (Modified from Marinelli et al. [13] and Rougé-Pont et al. [71]).

tion induced by cocaine and amphetamine (52,53), and other stressors such as mild tail pressure, foot shock, restraint/immobilization, handling, social isolation, or social defeat also have similar effects (48,49,51,54-56).

The enhancing effects of stress on drug self-administration have been described for decades. Again, different stressors such as tail pinch (50), foot shock (57), social isolation (58,59), social stress (60-62), and food restriction (63-67) all increase intravenous self-administration of amphetamine and cocaine. These effects have been observed for different doses of the drugs, during the acquisition phase, the retention one, as well as in progressive ratio schedules.

Was this article helpful?

0 0
Drug Addiction Report

Drug Addiction Report

You're going to discover so many things on addiction with little effort Not only will you discover the thrill of breaking free from your addiction, but you'll also learn extra bonus tips to actually help other people This new breakthrough book is a guide, really. A guide as a result of years of searching, studying, and scouring hundreds of websites, stores, and magazines.

Get My Free Ebook


Post a comment